Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Repetitive brain trauma is associated with a progressive neurological deterioration, now
termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in …

The microtubule-associated protein tau and amyloid-β (Aβ) are key players in Alzheimer's
disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau …

Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

Stress can affect cognition in many ways, with the outcome (ie, facilitating or impairing)
depending on a combination of factors related to both stress and the cognitive function …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central
nervous system, ranging from the regulation of gene transcription, cellular signaling …

Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease
typically characterized by memory loss, personality changes, and a decline in overall …

The microbiota–gut–brain axis plays an important role in the development of
neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence …