Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby serve as
the protein anchors and determinants of 3D genome organization. Conversely, chromatin …

The nuclear pore complex (NPC) is the massive protein assembly that regulates the
transport of macromolecules between the nucleus and the cytoplasm. Recent breakthroughs …

Nucleoporin proteins (Nups) have been proposed to mediate spatial and temporal
chromatin organization during gene regulation. Nevertheless, the molecular mechanisms in …

Precise control of gene expression during differentiation relies on the interplay of chromatin
and nuclear structure. Despite an established contribution of nuclear membrane proteins to …

Virtually all cell types have the same DNA, yet each type exhibits its own cell-specific pattern
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …

The gene balance hypothesis postulates that there is selection on gene copy number (gene
dosage) to preserve the stoichiometric balance among interacting proteins. This …

The nuclear pore complex (NPC) is a giant protein assembly that penetrates the double
layers of the nuclear membrane. The overall structure of the NPC has approximately …

Nuclear pore complexes are multiprotein channels that span the nuclear envelope, which
connects the nucleus to the cytoplasm. In addition to their main role in the regulation of …

The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish
their replication and to suppress the host immune response. Viruses encode many factors …