Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Unnatural amino acids (UAAs) have gained significant attention in protein engineering and
drug development owing to their ability to introduce new chemical functionalities to proteins …

Electrochemistry has recently emerged as a powerful approach in small-molecule synthesis
owing to its numerous attractive features, including precise control over the fundamental …

Heterologous tRNAs used for noncanonical amino acid (ncAA) mutagenesis in mammalian
cells typically show poor activity. We recently introduced a virus‐assisted directed evolution …

Antibody–drug conjugates (ADCs) have emerged as a powerful class of anticancer
therapeutics that enable the selective delivery of toxic payloads into target cells. There is …

Many systemic cancer chemotherapies comprise a combination of drugs, yet all clinically
used antibody–drug conjugates (ADCs) contain a single-drug payload. These combination …

The Escherichia coli leucyl-tRNA synthetase (EcLeuRS)/tRNAEcLeu pair has been
engineered to genetically encode a structurally diverse group of enabling noncanonical …

Proteins represent powerful biomacromolecules due to their unique functionality and broad
utility both in the cell and in non‐biological applications. The genetic encoding of non …

Incorporation of more than one noncanonical amino acid (ncAA) within a single protein
endows the resulting construct with multiple useful features such as augmented molecular …

Suppressor transfer RNAs (sup-tRNAs) are receiving renewed attention for their promising
therapeutic properties in treating genetic diseases caused by nonsense mutations …