Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

[HTML][HTML] A critical review of the epidemiological evidence of effects of air pollution on dementia, cognitive function and cognitive decline in adult population

JM Delgado-Saborit, V Guercio, AM Gowers… - Science of the Total …, 2021 - Elsevier
Dementia is arguably the most pressing public health challenge of our age. Since dementia
does not have a cure, identifying risk factors that can be controlled has become paramount …

Heavy metals exposure and Alzheimer's disease and related dementias

KM Bakulski, YA Seo, RC Hickman… - Journal of …, 2020 - content.iospress.com
Alzheimer's disease and related dementias lack effective treatment or cures and are major
public health challenges. Risk for Alzheimer's disease and related dementias is partially …

Association between heavy metal exposure and Parkinson's disease: a review of the mechanisms related to oxidative stress

S Pyatha, H Kim, D Lee, K Kim - Antioxidants, 2022 - mdpi.com
Parkinson's disease (PD) is a gradually progressing neurodegenerative condition that is
marked by a loss of motor coordination along with non-motor features. Although the precise …

Are noise and air pollution related to the incidence of dementia? A cohort study in London, England

IM Carey, HR Anderson, RW Atkinson, SD Beevers… - BMJ open, 2018 - bmjopen.bmj.com
Objective To investigate whether the incidence of dementia is related to residential levels of
air and noise pollution in London. Design Retrospective cohort study using primary care …

Role of environmental contaminants in the etiology of Alzheimer's disease: a review

M Yegambaram, B Manivannan… - Current Alzheimer …, 2015 - ingentaconnect.com
Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70%
risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include …

A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line

A Soubry, C Hoyo, RL Jirtle, SK Murphy - Bioessays, 2014 - Wiley Online Library
Literature on maternal exposures and the risk of epigenetic changes or diseases in the
offspring is growing. Paternal contributions are often not considered. However, some animal …

Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

[HTML][HTML] Doença de Alzheimer: hipóteses etiológicas e perspectivas de tratamento

AD Falco, DS Cukierman, RA Hauser-Davis, NA Rey - Química Nova, 2016 - SciELO Brasil
With the increase in life expectancy registered in the past few decades, the prevalence of
various medical conditions related to aging has been observed, such as dementia and …

Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases

MA Rahman, MS Rahman, MJ Uddin… - … Science and Pollution …, 2020 - Springer
Neurodegenerative disorders are typically sporadic in nature in addition to usually
influenced through an extensive range of environmental factors, lifestyle, and genetic …