It is now established that sex differences occur in clinical manifestation, disease
progression, and prognosis for both cardiovascular (CVDs) and central nervous system …

The dense neuropil of the central nervous system leaves only limited space for extracellular
substances free. The advent of immunohistochemistry, soon followed by advanced …

The cause of the loss of basal forebrain cholinergic neurons (BFCNs) and their terminal
synapses in the cerebral cortex and hippocampus in Alzheimer's disease (AD) has provoked …

Alzheimer's disease (AD) is a major contributor to dementia and the most common
neurodegenerative disorder. In AD pathophysiology, matrix metalloproteinases (MMPs) …

Nerve growth factor (NGF) and its precursor form, proNGF, are critical for neuronal survival
and cognitive function. In the brain, proNGF is the only detectable form of NGF …

Several neurodegenerative diseases are characterized by the accumulation of aggregated
misfolded proteins. These pathological agents have been suggested to propagate in the …

Introduction Alzheimer's disease (AD) can be characterised in vivo by biomarkers reflecting
amyloid-β (Aβ) and tau pathology. However, there is a need for biomarkers reflecting …

Background The discovery that nerve growth factor (NGF) metabolism is altered in Down
syndrome (DS) and Alzheimer's disease (AD) brains offered a framework for the …

Alzheimer's disease is characterized by two major neuropathological hallmarks—the
extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of …

Late-onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's disease
(AD). However, modeling sporadic LOAD that endogenously captures hallmark neuronal …