This review will describe the structure and function of the eosinophil. The roles of several
relevant cell surface molecules and receptors will be discussed. We will also explore the …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …

Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold has gained considerable scientific
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …

Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Asthma affects approximately 300 million people worldwide and approximately 7.5% of
adults in the United States. 1, 2 Among adults, asthma results in about 10.5 million physician …

Background: The immunomodulatory properties of Nigella sativa seed, as a basis of its
clinical applications by many cultures have been reviewed. Thymoquinone (TQ) is one of the …

Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-
inflammatory responses associated with allergic disorders. While selective inhibition of …

Leukotrienes are pro-inflammatory lipid mediators, which are biosynthesized via the
lipoxygenase pathway of the arachidonic acid cascade. Lipoxygenases form a family of lipid …

Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for
the treatment of asthma in both children and adults. However, its effectiveness is debated …