Renal fibrosis is the ultimate presentation of chronic kidney disease, which progresses to
end-stage renal disease. Hydroxychloroquine (HCQ) has been adapted for the treatment of …

Caffeine has been demonstrated to possess anti-fibrotic activity against liver fibrosis.
However, its role in renal fibrosis remained unclear. This study investigated the effects of …

Renal fibrosis is a hallmark of chronic kidney disease. Although considerable achievements
in the pathogenesis of renal fibrosis have been made, the underlying mechanisms of renal …

Hypoxia can cause Epithelial–mesenchymal transition (EMT) in renal tubular cells, and in
turn, renal fibrosis. We tested the expression of TRIM46, a member of tripartite motif …

Fibrosis is characterized by excess deposition of extracellular matrix (ECM). However, the
ECM changes during fibrosis not only quantitatively but also qualitatively. Thus, the …

OBJECTIVE: To investigate the effect of Huangqi decoction (黄芪汤) on renal interstitial
fibrosis and its association with the transforming growth factor-β1 (TGF-β1)/mitogen …

Chronic kidney diseases usually cause renal interstitial fibrosis, the prevention, delay, and
treatment of which is a global research hotspot. However, no definite treatment options are …

Background. The aim of the present study was to investigate the therapeutic potential of
metformin in preventing cyclosporine A (CsA)-induced nephrotoxicity. Methods. Three …

Ochratoxin A (OTA) was reported to induce proximal tubules nephrotoxicity in humans and
animals. However, the toxicity of OTA on glomeruli has rarely been studied. We investigated …

Abstract Background/Aim To assess the correlation between serum uric acid (UA) level and
diabetic kidney disease (DKD) in Type 1 diabetes (T1DM) patients in Anhui, China. Methods …