Most patients diagnosed with head and neck squamous cell carcinoma (HNSCC) will
present with locally advanced disease, requiring multimodality therapy. While this approach …

Human papilloma viruses (HPV) are a small group of non‑enveloped viruses belonging to
the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles …

PURPOSE Mutations in the HRAS (m HRAS) proto-oncogene occur in 4%-8% of patients
with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) …

The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …

Epigenetic changes are defined as inherited modifications that are not present in DNA
sequence. Gene expression is regulated at various levels and not only in response to DNA …

Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …

Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth
factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic …

Background Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of
recurrence, and with few approved targeted agents, novel treatments are needed. We …

Introduction RSL3-induced ferroptosis is a cell death pathway dependent upon intracellular
iron and is characterized by accumulation of lipid hydroperoxides. Glutaminolysis, a …

Simple Summary IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a signal
scaffolding protein that regulates a range of cellular activities by facilitating signal …