Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

Aging animals display a broad range of progressive degenerative changes, and one of the
most fascinating is the decline of female reproductive function. In the model organism …

Notch signaling regulates stem cells across animal phylogeny. C. elegans Notch signaling
activates transcription of two genes, lst-1 and sygl-1, that encode potent regulators of …

Pheromones exchanged by conspecifics are a major class of chemical signals that can alter
behavior, physiology, and development. In particular, males and females communicate with …

Diapause is a state of developmental arrest adopted in response to or in anticipation of
environmental conditions that are unfavorable for growth. In many cases, diapause is …

Temperature influences male fertility across organisms; however, how suboptimal
temperatures affect adult spermatogenesis remains understudied. In a recent study on …

Stem cell systems are essential for the development and maintenance of polarized tissues.
Intercellular signaling pathways control stem cell systems, where niche cells signal stem …

Mitochondria harbor an independent genome, called mitochondrial DNA (mtDNA), which
contains essential metabolic genes. Although mtDNA mutations occur at high frequency …

To study how natural allelic variation explains quantitative developmental system variation,
we characterized natural differences in germ stem cell niche activity, measured as …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …