Telomerase structural biology comes of age
Telomerase is an RNA–protein complex comprising telomerase reverse transcriptase, a non-
coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or …
coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or …
Post-transcriptional and post-translational modifications in telomerase biogenesis and recruitment to telomeres
N Shepelev, O Dontsova, M Rubtsova - International Journal of Molecular …, 2023 - mdpi.com
Telomere length is associated with the proliferative potential of cells. Telomerase is an
enzyme that elongates telomeres throughout the entire lifespan of an organism in stem cells …
enzyme that elongates telomeres throughout the entire lifespan of an organism in stem cells …
The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme
The telomerase holoenzyme is critical for maintaining eukaryotic genome integrity. In
addition to a reverse transcriptase and an RNA template, telomerase contains additional …
addition to a reverse transcriptase and an RNA template, telomerase contains additional …
Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs
Q Peng, Y Wang, Y Xiao, H Chang, S Luo, D Wang… - Science …, 2023 - science.org
U6 and 7SK snRNAs have a 5′ cap, believed to be essential for their stability and
maintained by mammalian MePCE or Drosophila Bin3 enzymes. Although both proteins are …
maintained by mammalian MePCE or Drosophila Bin3 enzymes. Although both proteins are …
The fission yeast methyl phosphate capping enzyme Bmc1 guides 2′-O-methylation of the U6 snRNA
J Porat, VA Slat, SD Rader… - Nucleic Acids Research, 2023 - academic.oup.com
Splicing requires the tight coordination of dynamic spliceosomal RNAs and proteins. U6 is
the only spliceosomal RNA transcribed by RNA Polymerase III and undergoes an extensive …
the only spliceosomal RNA transcribed by RNA Polymerase III and undergoes an extensive …
Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster
Abstract Methylphosphate Capping Enzyme (MePCE) monomethylates the gamma
phosphate at the 5′ end of the 7SK noncoding RNA, a modification thought to protect 7SK …
phosphate at the 5′ end of the 7SK noncoding RNA, a modification thought to protect 7SK …
LARP3, LARP7, and MePCE are Involved in the Early Stage of Human Telomerase RNA Biogenesis
CK Tseng, TL Kao, YH Chen, YC Huang, P Baumann - 2023 - researchsquare.com
Human telomerase assembly is a highly dynamic process. Using biochemical approaches,
we found that LARP3 and LARP7/MePCE are involved in the early stage and that their …
we found that LARP3 and LARP7/MePCE are involved in the early stage and that their …
The fission yeast methylphosphate capping enzyme Bmc1/Bin3 promotes 2'-O-methylation of U6 and pre-mRNA splicing
J Porat, VA Slat, SD Rader, MA Bayfield - bioRxiv, 2023 - biorxiv.org
Efficient splicing requires the tight coordination of dynamic spliceosomal RNAs and proteins.
U6 is the only spliceosomal RNA transcribed by RNA Polymerase III and undergoes an …
U6 is the only spliceosomal RNA transcribed by RNA Polymerase III and undergoes an …
The methyl phosphate capping enzyme Bin3 is a stable component of the fission yeast telomerase holoenzyme
The telomerase holoenzyme is critical for maintaining eukaryotic genome integrity. In
addition to a reverse transcriptase and an RNA template, telomerase contains additional …
addition to a reverse transcriptase and an RNA template, telomerase contains additional …