The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Pluripotent stem cells progressing to the clinic

A Trounson, ND DeWitt - Nature reviews Molecular cell biology, 2016 - nature.com
Basic experimental stem cell research has opened up the possibility of many diverse clinical
applications; however, translation to clinical trials has been restricted to only a few diseases …

Bone marrow-derived mesenchymal stem cells reverse radiotherapy-induced premature ovarian failure: emphasis on signal integration of TGF-β, Wnt/β-catenin and …

MO El-Derany, RS Said, E El-Demerdash - Stem Cell Reviews and …, 2021 - Springer
Radiotherapy is an indispensable cancer treatment approach. However, it is associated with
hazardous consequences on multiple organs characterized by insidious worsening severity …

Evaluating the in vitro therapeutic effects of human amniotic mesenchymal stromal cells on MiaPaca2 pancreatic cancer cells using 2D and 3D cell culture model

Z Rahmani, F Safari - Tissue and Cell, 2021 - Elsevier
Human amniotic mesenchymal stromal cells (hAMSCs) are considered as a population of
multipotent cells. The molecular events associated with mesenchymal stromal cell …

Fibroblast Growth Factor Type 1 (FGF1)-Overexpressed Adipose-Derived Mesenchaymal Stem Cells (AD-MSCFGF1) Induce Neuroprotection and Functional …

H Ghazavi, SJ Hoseini… - Stem Cell Reviews and …, 2017 - Springer
Stroke, as the second most common cause of death, imposes a great financial burden on
both the individual and society. Mesenchymal stem cells from rodents have demonstrated …

Engineered stem cell niche matrices for rotator cuff tendon regenerative engineering

MS Peach, DM Ramos, R James, NL Morozowich… - PloS one, 2017 - journals.plos.org
Rotator cuff (RC) tears represent a large proportion of musculoskeletal injuries attended to at
the clinic and thereby make RC repair surgeries one of the most widely performed …

In vitro evaluation of autophagy and cell death induction in Panc1 pancreatic cancer by secretome of hAMSCs through downregulation of p-AKT/p-mTOR and …

F Safari, F Dadvar - Tissue and Cell, 2023 - Elsevier
One of the main causes of cancer mortality in the world is pancreatic cancer. Therapies
based on stem cells are currently thought to be a hopeful option in the treatment of cancer …

Long non-coding RNA H19 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by regulating microRNA-140-5p/SATB2 axis

HU Bi, D Wang, X Liu, G Wang, X Wu - Journal of biosciences, 2020 - Springer
The osteogenic differentiation of mesenchymal stem cells (MSCs) has potential clinical
values in the treatment of bone-related diseases. Long non-coding RNA H19 and microRNA …

Downregulation of Pinkbar/pAKT and MMP2/MMP9 expression in MDA-MB-231 breast cancer cells as potential targets in cancer therapy by hAMSCs Secretome

T Shakery, F Safari - Cells Tissues Organs, 2023 - karger.com
Breast cancer is one of the leading causes of cancer-related deaths among women
worldwide. Cancer therapy based on stem cells is considered as a novel and promising …

Multi-effects of Resveratrol on stem cell characteristics: Effective dose, time, cell culture conditions and cell type-specific responses of stem cells to Resveratrol

Z Safaeinejad, F Kazeminasab, A Kiani-Esfahani… - European journal of …, 2018 - Elsevier
Stem cells which defined by dual features of self-renewal and differentiation potential
provide a unique source for repairing damaged tissues to treat a wide spectrum of diseases …