Frontotemporal lobar degeneration (FTLD) is the second most common form of dementia
after Alzheimer's disease. The study and the dissection of FTLD is complex due to its clinical …

Neuroinflammation is involved in the aetiology of many neurodegenerative disorders
including Alzheimer's disease, Parkinson's disease and motor neuron disease. Whether …

Objective: To analyze the clinical utility of 3 CSF biomarkers and their structural imaging
correlates in a large cohort of patients with different dementia and parkinsonian syndromes …

Background Clinical, pathological and genetic overlap between sporadic frontotemporal
dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been …

Importance Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by loss of upper and lower motor neurons. Although novel ALS genetic …

Background Microglial dysfunction is implicated in frontotemporal lobar degeneration
(FTLD). Although studies have reported excessive microglial activation or senescence …

Methods We investigated the frequencies and mutations in neurodegenerative disease
genes in 121 consecutive FTD subjects using an unbiased, combined sequencing …

Accumulation and propagation of hyperphosphorylated Tau (p-Tau) is a common
neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD) …

Introduction Aortic aneurysms (AA) are prevalent worldwide with a notable absence of drug
therapies. Thus, identifying potential drug targets is of utmost importance. AA often presents …

Background Frontotemporal dementia is an increasingly studied disease, the underlying
functional impairments on a neurobiological level of which have not been fully understood …