Recently, evidence has emerged that seven transmembrane G protein-coupled receptors
may be present as homo-and heteromers in the plasma membrane. Here we describe a new …

The ability of the closely related β 2-and β 3-adrenergic receptors (AR) to form hetero-
oligomers was assessed by bioluminescence resonance energy transfer. Quantitative …

Dopamine D1-like receptors consisting of D1 and D5 subtypes are intimately implicated in
dopaminergic regulation of fundamental neurophysiologic processes such as mood …

Protein-protein interactions are involved in the regulation of a large number of biological
processes. It is well established that a variety of cell surface receptors interact with each …

A polyclonal antibody directed towards the last 73 amino acid residues of the rat type 1
cannabinoid (CB1) receptor strongly and exclusively labels a high molecular weight …

Wnt signaling has an important role in cell-fate determination, tissue patterning and
tumorigenesis. Wnt proteins signal through seven-pass transmembrane receptors of the …

We have demonstrated previously that the chemokine receptors CCR2 and CCR5 form
homo-and heterodimers and that dimers can only bind a single chemokine molecule with …

The growing recognition that members of the rhodopsin-like family A G-protein-coupled
receptors (GPCRs) exist and function as dimers or higher-order oligomers, and that GPCR …

Homo-and heterodimerization of the opioid receptors with functional consequences were
reported previously. However, the exact nature of these putative dimers has not been …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1-3 G …