Dexmedetomidine is a new generation highly selective α2-adrenergic receptor (α2-AR)
agonist that is associated with sedative and analgesic sparing effects, reduced delirium and …

Background Neuraxial application of dexmedetomidine (DEX) as adjuvant analgesic has
been invetigated in some randomized controlled trials (RCTs) but not been approved …

Growing and consistent preclinical evidence, combined with early clinical epidemiological
observations, suggest potentially neurotoxic effects of commonly used anesthetic agents in …

The introduction of newer more selective α− 2 adrenergic agonist, dexmedetomidine has
made a revolution in the field of anesthesia owing to its varied application. The aim of the …

Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-
lowering medications in migraine prophylaxis are unknown. Leveraging large-scale …

To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in
acute and persistent pain behavior assays. One of the lines from this screen, which …

Pain is a complex multidimensional concept that facilitates the initiation of the signaling
cascade in response to any noxious stimuli. Action potential generation in the peripheral …

Background Aim of the current meta‐analysis was to assess the effects of intraoperative
dexmedetomidine on postoperative pain, analgesic consumption, and adverse events in …

α2‐Adrenoceptors are important mediators of physiological responses to the endogenous
catecholamines noradrenaline and adrenaline. In addition, α2‐adrenoceptors are …

Agonists of α2‐adrenoceptors are increasingly being used for the provision of comfort,
sedation and the management of delirium in critically ill patients, with and without sepsis. In …