A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

M Jadaliha, O Gholamalamdari, W Tang, Y Zhang… - PLoS …, 2018 - journals.plos.org
The human genome encodes thousands of long noncoding RNA (lncRNA) genes; the
function of majority of them is poorly understood. Aberrant expression of a significant …

Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma

L Hu, Y Wu, D Tan, H Meng, K Wang, Y Bai… - Journal of experimental & …, 2015 - Springer
Abstract Background Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
has been demonstrated to be an important player in various human malignancies; it is …

Hyperglycemia associated metabolic and molecular alterations in cancer risk, progression, treatment, and mortality

P Ramteke, A Deb, V Shepal, MK Bhat - Cancers, 2019 - mdpi.com
Cancer and diabetes are amongst the leading causes of deaths worldwide. There is an
alarming rise in cancer incidences and mortality, with approximately 18.1 million new cases …

Long non-coding RNA in health and disease

PG Maass, FC Luft, S Bähring - Journal of molecular medicine, 2014 - Springer
Long non-coding RNAs (lncRNAs) interact with the nuclear architecture and are involved in
fundamental biological mechanisms, such as imprinting, histone-code regulation, gene …

lncRNAs: insights into their function and mechanics in underlying disorders

X Li, Z Wu, X Fu, W Han - Mutation Research/Reviews in Mutation …, 2014 - Elsevier
Genomes of complex organisms are characterized by the pervasive expression of different
types of noncoding RNAs (ncRNAs). lncRNAs constitute a large family of long—arbitrarily …

Long non-coding RNA FGF13-AS1 inhibits glycolysis and stemness properties of breast cancer cells through FGF13-AS1/IGF2BPs/Myc feedback loop

F Ma, XU Liu, S Zhou, W Li, C Liu, M Chadwick, C Qian - Cancer letters, 2019 - Elsevier
LncRNAs have been proven to play crucial roles in various processes of breast cancer.
LncRNA FGF13-AS1 has been identified as one of the 25 downregulated lncRNAs in breast …

Oligonucleotide therapies for disorders of the nervous system

O Khorkova, C Wahlestedt - Nature biotechnology, 2017 - nature.com
Oligonucleotide therapies are currently experiencing a resurgence driven by advances in
backbone chemistry and discoveries of novel therapeutic pathways that can be uniquely and …

Transcriptome analysis of triple-negative breast cancer reveals an integrated mRNA-lncRNA signature with predictive and prognostic value

YZ Jiang, YR Liu, XE Xu, X Jin, X Hu, KD Yu, ZM Shao - Cancer research, 2016 - AACR
While recognized as a generally aggressive disease, triple-negative breast cancer (TNBC)
is highly diverse in different patients with variable outcomes. In this prospective …

LncRNA DGCR5 promotes lung adenocarcinoma (LUAD) progression via inhibiting hsa‐mir‐22‐3p

HX Dong, R Wang, XY Jin, J Zeng… - Journal of cellular …, 2018 - Wiley Online Library
Long non‐coding RNAs (lncRNAs) serve critical roles in the pathogenesis of various
cancers, including lung adenocarcinoma (LUAD). Herein, in this study, we aimed to …

Noncoding RNAs in neurodegeneration

E Salta, B De Strooper - Nature Reviews Neuroscience, 2017 - nature.com
The emerging complexity of the transcriptional landscape poses great challenges to our
conventional preconceptions of how the genome regulates brain function and dysfunction …