Anatomy, Function, and Dysfunction of the Right Ventricle: JACC State-of-the-Art Review

J Sanz, D Sánchez-Quintana, E Bossone… - Journal of the American …, 2019 - jacc.org
There is increasing recognition of the crucial role of the right ventricle (RV) in determining
functional status and prognosis in multiple conditions. The normal RV is anatomically and …

Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update

AV Noordegraaf, KM Chin, F Haddad… - European …, 2019 - Eur Respiratory Soc
The function of the right ventricle determines the fate of patients with pulmonary
hypertension. Since right heart failure is the consequence of increased afterload, a full …

The relationship between the right ventricle and its load in pulmonary hypertension

A Vonk Noordegraaf, BE Westerhof… - Journal of the American …, 2017 - jacc.org
In pulmonary hypertension, the right ventricle adapts to the increasing vascular load by
enhancing contractility (“coupling”) to maintain flow. Ventriculoarterial coupling implies that …

The physiological basis of pulmonary arterial hypertension

R Naeije, MJ Richter, LJ Rubin - European Respiratory Journal, 2022 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a
progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) …

Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. An Official American Thoracic Society Research Statement

T Lahm, IS Douglas, SL Archer, HJ Bogaard… - American journal of …, 2018 - atsjournals.org
Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …

An official European Respiratory Society statement: pulmonary haemodynamics during exercise

G Kovacs, P Herve, JA Barbera… - European …, 2017 - Eur Respiratory Soc
There is growing recognition of the clinical importance of pulmonary haemodynamics during
exercise, but several questions remain to be elucidated. The goal of this statement is to …

Pulmonary hypertension in heart failure: pathophysiology, pathobiology, and emerging clinical perspectives

M Guazzi, R Naeije - Journal of the American College of Cardiology, 2017 - jacc.org
Pulmonary hypertension is a common hemodynamic complication of heart failure. Interest in
left-sided pulmonary hypertension has increased remarkably in recent years because its …

Reserve of right ventricular-arterial coupling in the setting of chronic overload

K Tello, A Dalmer, J Axmann, R Vanderpool… - Circulation: Heart …, 2019 - Am Heart Assoc
Background: Right ventricular (RV) maladaptation and failure determine outcome in
pulmonary hypertension. The adaptation of RV function to loading (RV-pulmonary arterial …

Right ventricular functional reserve in pulmonary arterial hypertension

S Hsu, BA Houston, E Tampakakis, AC Bacher… - Circulation, 2016 - Am Heart Assoc
Background—Right ventricular (RV) functional reserve affects functional capacity and
prognosis in patients with pulmonary arterial hypertension (PAH). PAH associated with …

Adaptive versus maladaptive right ventricular remodelling

ZA Rako, N Kremer, A Yogeswaran… - ESC Heart …, 2023 - Wiley Online Library
Right ventricular (RV) function and its adaptation to increased afterload [RV–pulmonary
arterial (PA) coupling] are crucial in various types of pulmonary hypertension, determining …