A longstanding question is how influenza virus evolves to escape human immunity, which is
polyclonal and can target many distinct epitopes. Here, we map how all amino-acid …

Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and
pandemic rises in illness and death. An error prone replication mechanism results in …

Drug-resistant Pseudomonas aeruginosa (PA) poses an emerging threat to human health
with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and …

Background Lassa fever is a substantial health burden in west Africa. We evaluated the
safety, tolerability, and immunogenicity of a recombinant, live-attenuated, measles-vectored …

While neutralizing antibody titers measured by hemagglutination inhibition have been
proposed as a correlate of protection following influenza vaccination, neutralization alone is …

Influenza viruses are one of the most prevalent respiratory pathogens known to humans and
pose a significant threat to global public health each year. Annual influenza epidemics are …

Antibody paratopes are formed by hypervariable complementarity-determining regions
(CDRH3s) and variable gene-encoded CDRs. The latter show biased usage in human …

Protection from influenza virus infection is canonically associated with antibodies that
neutralize the virus by blocking the interaction between the viral hemagglutinin and host cell …

The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes
in vaccine composition. Recent seasonal H3 vaccines do not protect against swine-origin …

Seasonal influenza virus epidemics represent a significant public health burden.
Approximately 25% of all influenza virus infections are caused by type B viruses, and these …