The stalk of the influenza virus hemagglutinin (HA) is an attractive target for antibody-based
universal influenza virus vaccine development. While antibodies that target this part of the …

Background Older adults are at high risk of influenza disease, but generally respond poorly
to vaccination. Antibody-dependent cellular cytotoxicity (ADCC) may be an important …

The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine
that elicits broad protection against different virus strains. Studies in preclinical models of …

Introduction: Antibodies directed against influenza virus execute their protective function by
exploiting a variety of effector mechanisms. Neutralizing antibodies have been thoroughly …

The DiversitabTM system produces target specific high titer fully human polyclonal IgG
immunoglobulins from transchromosomic (Tc) bovines shown to be safe and effective …

Antibodies represent the primary correlate of immunity following most clinically approved
vaccines. However, their mechanisms of action vary from pathogen to pathogen, ranging …

Influenza virus remains a serious public health burden due to ongoing viral evolution.
Vaccination remains the best measure of prophylaxis, yet current seasonal vaccines elicit …

Engaging the antibody-dependent cell-mediated cytotoxicity (ADCC) for killing of virus-
infected cells and secretion of antiviral cytokines and chemokines was incorporated as one …

Vaccination is the most effective countermeasure to reduce the severity of influenza. Current
seasonal influenza vaccines mainly elicit humoral immunity targeting hemagglutinin (HA). In …