The continued evolution of influenza viruses reduces the effectiveness of vaccination and
antiviral drugs. The identification of novel and universal agents for influenza prophylaxis and …

Classic chimeric hemagglutinin (cHA) was designed to induce immune responses against
the conserved stalk domain of HA. However, it is unclear whether combining more than one …

Viral respiratory tract infections are the most common human ailments, leading to enormous
health and economic burden. Hundreds of viral species and subtypes have been associated …

Split inactivated influenza vaccines remain one of the primary preventative strategies
against severe influenza disease in the population. However, current vaccines are only …

Recent studies have revealed multiple roles for Fc gamma receptors (FcγRs) in broad
immunity against influenza viruses. Activating FcγR pathways can be harnessed to confer …

Zoster vaccines generate antibody responses against varicella-zoster virus (VZV). We
compared antibody-dependent cell cytotoxicity (ADCC) elicited by zoster vaccine live (ZVL) …

Influenza viruses cause occasional pandemics and annual epidemics, thus persist as a
threat to human society. The high variability of viral envelope proteins resulting from …

Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza
A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer …

Influenza A virus (IAV) and influenza B virus (IBV) cause substantial morbidity and mortality
during annual epidemics. Two distinct lineages of IBV are distinguished, based on variation …

Seasonal influenza vaccination takes into account primarily hemagglutinin (HA)-specific
neutralizing antibody responses. However, the accumulation of substitutions in the antigenic …