Klotho is an anti-ageing protein that functions in many pathways that govern ageing, like
regulation of phosphate homeostasis, insulin signaling, and Wnt signaling. Klotho …

We are entering a new era of mouse phenomics, driven by large-scale and economical
generation of mouse mutants coupled with increasingly sophisticated and comprehensive …

Klotho is a renal protein involved in phosphate homeostasis, which is downregulated in
renal disease. It has long been considered an antiaging factor. Two Klotho gene transcripts …

Abstract α-Klotho is well described as an anti-aging protein, with critical roles in kidney
function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α …

Heterozygous germline gain-of-function mutations of G-protein subunit α 11 (Gα 11), a
signaling partner for the calcium-sensing receptor (CaSR), result in autosomal dominant …

Phosphate, a component of nucleic acids, DNA and RNA, is incorporated in the structure of
phospholipids in cell membranes, and is involved in many biological functions such as cell …

Osteoporosis is a complex genetic disease in which the number of loci associated with the
bone mineral density, a clinical risk factor for fracture, has increased at an exponential rate …

The adaptor protein 2 sigma subunit (AP2σ), encoded by AP2S1, forms a heterotetrameric
complex, with AP2α, AP2β, and AP2μ subunits, that is pivotal for clathrin mediated …

Loss-of-function mutations of GNA11, which encodes G-protein subunit α 11 (Gα 11), a
signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric …

Non-syndromic kyphosis is a common disorder that is associated with significant morbidity
and has a strong genetic involvement; however, the causative genes remain to be identified …