Redefining the bacterial Type I protein secretion system

FJ Hodges, LT Von Vergel, AF Cunningham… - Advances in Microbial …, 2023 - Elsevier
Type I secretion systems (T1SS) are versatile molecular machines for protein transport
across the Gram-negative cell envelope. The archetypal Type I system mediates secretion of …

Progress toward a vaccine for extraintestinal pathogenic E. coli (ExPEC) II: efficacy of a toxin-autotransporter dual antigen approach

Y Xing, JR Clark, JD Chang, JJ Zulk… - Infection and …, 2024 - Am Soc Microbiol
ABSTRACT Extraintestinal pathogenic Escherichia coli (ExPEC) is a leading cause of
worldwide morbidity and mortality, the top cause of antimicrobial-resistant (AMR) infections …

[HTML][HTML] Molecular insights into capsular polysaccharide secretion

J Kuklewicz, J Zimmer - Nature, 2024 - nature.com
Capsular polysaccharides (CPSs) fortify the cell boundaries of many commensal and
pathogenic bacteria. Through the ABC-transporter-dependent biosynthesis pathway, CPSs …

[HTML][HTML] Type 1 secretion necessitates a tight interplay between all domains of the ABC transporter

MT Anlauf, FL Bilsing, J Reiners, O Spitz, E Hachani… - Scientific Reports, 2024 - nature.com
Type I secretion systems (T1SS) facilitate the secretion of substrates in one step across both
membranes of Gram-negative bacteria. A prime example is the hemolysin T1SS which …

[HTML][HTML] Investigations on the substrate binding sites of hemolysin B, an ABC transporter, of a type 1 secretion system

Z Pourhassan N, E Hachani, O Spitz… - Frontiers in …, 2022 - frontiersin.org
The ABC transporter hemolysin B (HlyB) is the key protein of the HlyA secretion system, a
paradigm of type 1 secretion systems (T1SS). T1SS catalyze the one-step substrate …

[HTML][HTML] A step forward to the optimized HlyA type 1 secretion system through directed evolution

ZN Pourhassan, H Cui, N Muckhoff, MD Davari… - Applied Microbiology …, 2023 - Springer
Secretion of proteins into the extracellular space has great advantages for the production of
recombinant proteins. Type 1 secretion systems (T1SS) are attractive candidates to be …

Structure of a dimeric ABC transporter

SC Bickers, S Benlekbir, JL Rubinstein, V Kanelis - bioRxiv, 2023 - biorxiv.org
ATP binding cassette (ABC) proteins generally couple ATP hydrolysis to the active transport
of solutes across cellular membranes. All ABC proteins contain a core structure of two …

Antimicrobial activity screening of Bacteroidota and genome-based analysis of their antimicrobial biosynthetic potential

D Garcia-Morena, MV Fernandez-Cantos, W Maathuis… - 2024 - researchsquare.com
The oral and gut microbiota constitute vastly diverse and complex ecosystems. Their
presence affects local and distal organs, thus having a major role in health and disease …

Identifizierung und funktionelle Analyse von Pathogenitätsfaktoren in Bartonella bacilliformis

AA Dichter - 2023 - publikationen.ub.uni-frankfurt.de
Die Carrión-Krankheit ist eine durch Vektoren übertragene vernachlässigte Tropenkrankheit
(neglected tropical disease), die in den südamerikanischen Andentälern auf einer Höhe von …

Erfðamengi Aeromonas: tilvist seytikerfa af týpu I og tengsl þeirra við meinvirkni

A Bergsveinsdóttir - skemman.is
Aeromonas er ættkvísl Gram-neikvæðra baktería sem valda sýkingum bæði í mönnum og
dýrum. Það eru margir þættir sem stuðla að meinvirkni ættkvíslarinnar og eru seytikerfi einn …