[HTML][HTML] Looking into endoplasmic reticulum stress: the key to drug-resistance of multiple myeloma?

G Wang, F Fan, C Sun, Y Hu - Cancers, 2022 - mdpi.com
Simple Summary Advances in treatment, especially with novel drugs, have dramatically
improved the survival of multiple myeloma (MM) patients recently. However, frequent …

[HTML][HTML] Current approach and novel perspectives in nasopharyngeal carcinoma: the role of targeting proteasome dysregulation as a molecular landmark in …

R Yarza, M Bover, MT Agulló-Ortuño… - Journal of Experimental …, 2021 - Springer
Nasopharyngeal carcinoma (NPC) represents a molecularly paradigmatic tumor given the
complex diversity of environmental as well as host dependent factors that are closely …

[HTML][HTML] Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment

L Liu, Z Yu, H Cheng, X Mao, W Sui, S Deng, X Wei… - Scientific Reports, 2020 - nature.com
Anaemia is the most common complication of myeloma and is associated with worse clinical
outcomes. Although marrow replacement with myeloma cells is widely considered a …

[HTML][HTML] Single-cell analysis of multiple myelomas refines the molecular features of bortezomib treatment responsiveness

SH Jung, SS Park, JY Lim, SY Sohn, NY Kim… - … & Molecular Medicine, 2022 - nature.com
Both the tumor and tumor microenvironment (TME) are crucial for pathogenesis and
chemotherapy resistance in multiple myeloma (MM). Bortezomib, commonly used for MM …

Controllable hydrogen release for gas-assisted chemotherapy and ultrasonic imaging of drug-resistant tumors

Y Wang, Y Liu, J Zhou, L Lin, C Jia, J Wang… - Chemical Engineering …, 2021 - Elsevier
Gas-assisted therapy and diagnosis of tumors have attracted extensive interest due to their
low toxicity and convenience, but are severely limited by the uncontrollable gas release. In …

[HTML][HTML] The evidence that 25 (OH) D3 and VK2 MK-7 vitamins influence the proliferative potential and gene expression profiles of multiple myeloma cells and the …

K Łuczkowska, P Kulig, B Baumert, B Machaliński - Nutrients, 2022 - mdpi.com
Multiple myeloma (MM) remains an incurable hematological malignancy. Bortezomib (BTZ)
is a proteasome inhibitor widely used in MM therapy whose potent activity is often hampered …

[HTML][HTML] A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment

K Chroma, Z Skrott, J Gursky, J Bacovsky… - Cell Death & …, 2022 - nature.com
Despite several approved therapeutic modalities, multiple myeloma (MM) remains an
incurable blood malignancy and only a small fraction of patients achieves prolonged …

Research progress in proteasome inhibitor resistance to multiple myeloma.

J Wu, J Liu - Zhong nan da xue xue bao. Yi xue ban= Journal of …, 2021 - europepmc.org
多发性骨髓瘤 (multiple myeloma, MM) 是一种高度异质性恶性浆细胞疾病. 蛋白酶体抑制剂
(proteasome inhibitors, PIs) 是治疗 MM 的一线药物, 硼替佐米, 伊莎佐米和卡非佐米也广泛 …

[PDF][PDF] Endoplasmic reticulum stress and proteasome inhibitors in multiple myeloma: room for improvement

T Kubicki, L Gil, D Dytfeld - Pol Arch Intern Med, 2021 - scholar.archive.org
In the last 2 decades, we witnessed unprecedented progress in multiple myeloma research.
The median survival times doubled, and with the introduction of subsequent new …

[HTML][HTML] 蛋白酶体抑制剂在多发性骨髓瘤中耐药的研究进展

吴姣, 刘竞 - Journal of Central South University Medical Sciences, 2021 - ncbi.nlm.nih.gov
多发性骨髓瘤(multiple myeloma, MM) 是一种高度异质性恶性浆细胞疾病。 蛋白酶体抑制剂(
proteasome inhibitors, PIs) 是治疗MM 的一线药物, 硼替佐米、 伊莎佐米和卡非佐米也广泛 …