Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Inflammation, a biological response of body tissues to harmful stimuli, is also known to be
involved in a host of diseases, such as obesity, atherosclerosis, rheumatoid arthritis, and …

Chronic activation of inflammatory pathways and suppressed interferon are hallmarks of
immunosuppressive tumors. Previous studies have shown that CD11b integrin agonists …

Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis,
cancer cell proliferation, and invasion. We demonstrate that CAFs also mediate tumor …

Chronic inflammation is being shown to be increasingly involved in the onset and
development of several pathological disturbances such as arteriosclerosis, obesity …

Background Apigenin is a non-toxic natural flavonoid that is abundantly present in common
fruits and vegetables. It has been reported that apigenin has various beneficial health effects …

Inflammation involves a coordinated, sequential, and self limiting sequence of events
controlled by positive and negative regulatory mechanisms. Recent studies have shown that …

Autosomal dominant (AD) NFKB1 deficiency is thought to be the most common genetic
etiology of common variable immunodeficiency (CVID). However, the causal link between …

Common variable immunodeficiency (CVID), characterized by recurrent infections, is the
most prevalent symptomatic antibody deficiency. In∼ 90% of CVID-affected individuals, no …

Alzheimer's disease (AD) and bipolar disorder (BD) are progressive brain disorders.
Upregulated mRNA and protein levels of neuroinflammatory and arachidonic acid (AA) …