Polygenic risk scores (PRSs) have become the standard for quantifying genetic liability in
the prediction of disease risks. PRSs are generally constructed as weighted sum scores of …

Melanoma and non-melanoma skin cancers (NMSCs) are the most frequent cancers of the
skin in white populations. An increased risk in the development of skin cancers has been …

We trained and validated risk prediction models for the three major types of skin cancer—
basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma—on a cross …

Basal cell carcinoma and squamous cell carcinoma are the most common skin cancers, and
have genetic overlap with melanoma, pigmentation traits, autoimmune diseases, and blood …

The rising incidence of cutaneous melanoma over the past few decades has prompted
substantial efforts to develop risk prediction models identifying people at high risk of …

Genome-wide association studies (GWAS) have identified a number of risk loci for
cutaneous melanoma. Cutaneous melanoma shares overlapping genetic risk (genetic …

Background Melanoma aetiology has been proposed to have two pathways, which are
determined by naevi and type of sun exposure and related to the anatomical site where …

The US Preventive Services Task Force (USPSTF) initially released its skin cancer
screening recommendations in 1996 and concluded that there was not enough evidence to …

Merino sheep represents a valuable genetic resource worldwide. In this study, we
investigated selection signatures in Merino (and Merino-derived) sheep breeds using …

The success of genome-wide association studies (GWAS) in identifying common, low-
penetrance variant-cancer associations for the past decade is undisputed. However …