Type I and type II interferons (IFN) are central to both combating virus infection and
modulating the antiviral immune response. Indeed, an absence of either the receptor for type …

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …

Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …

Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

Background & Aims Chronic hepatitis C virus infection activates an intrahepatic immune
response, leading to increased expression of interferon (IFN)-stimulated genes and …

Natural killer (NK) cells are enriched in lymphocytes within the liver and have unique
phenotypic features and functional properties, including tumor necrosis factor–related …

While type I interferons (IFNs) are universally acknowledged for their antiviral and
immunostimulatory functions, there is increasing appreciation of the detrimental effects of …

Five human hepatitis viruses cause most of the acute and chronic liver disease worldwide.
Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest …

BACKGROUND & AIMS: A better understanding of the immunomodulatory effects of
PegIFNα therapy could allow more rational optimisation of future therapeutic approaches in …

Despite development of new antiviral drugs, viral infections are still a major health problem.
The most potent antiviral defense mechanism is the innate production of type I interferon …