SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …

High blood pressure (BP) presents a significant public health challenge. Recent findings
suggest that altered microbiota can exert a hypertensive effect on the host. One of the …

Silica is an essential substrate of various materials, and inhaling silica induces pulmonary
diseases potentially associated with macrophage pyroptosis. Utilizing silica of micro-and …

Ca2+ signaling is implicated in the transition between microglial surveillance and activation.
Several L-type Ca2+ channel blockers (CCBs) have been shown to ameliorate …

Pyroptosis is a type of programmed cell death that is generally upregulated during
atherosclerosis (AS). Magnesium, an important cation in the body, has exhibited an …

This study investigated the effect and mechanism of chrysosplenol D (CD) on LPS-induced
acute lung injury in mice. Histological changes in the lungs were measured by hematoxylin …

Rheumatoid arthritis (RA) is now widely recognized as a chronic systemic inflammatory
autoimmune disease characterized by swelling, pain and stiffness, which are often …

Alcoholic liver disease is one of the most common chronic liver diseases in the world. It is a
liver disease caused by prolonged heavy drinking and its main clinical features are nausea …

Introduction Lomerizine is a calcium channel blocker that crosses the blood–brain barrier
and is used clinically in the treatment of migraines. However, whether lomerizine is …

Infertility, abortion, and stillbirth caused by endometritis are the main factors affecting fertility
in ruminants. Lipopolysaccharide (LPS)-mediated inflammation is the main cause of …