Pharmacodynamics of combined estrogen-progestin oral contraceptives 3. Inhibition of ovulation

C Bastianelli, M Farris, E Rosato, I Brosens… - Expert Review of …, 2018 - Taylor & Francis
Introduction: Following a historical overview, the ovulation-inhibiting effect of various orally
administered estrogen-progestin combinations (combined oral contraceptives [COCs]) are …

Progestational and androgenic receptor binding affinities and in vivo activities of norgestimate and other progestins

A Phillips, K Demarest, DW Hahn, F Wong, JL McGuire - Contraception, 1990 - Elsevier
The progestational and androgenic in vitro receptor binding affinity and the in vivo activity of
norgestimate was compared with that of its metabolites and other progestins. The relative …

Clinical aspects of three new progestogens: desogestrel, gestodene, and norgestimate

RA Chez - American Journal of Obstetrics and Gynecology, 1989 - Elsevier
Three new 19-nortestosterone progestogens, which are chemically related to levonorgestrel,
are now clinically available in combination oral contraceptives in Europe. Desogestrel and …

Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs

F Fan, R Hu, A Munzli, Y Chen, RT Dunn… - Toxicological …, 2015 - academic.oup.com
Off-target effects of drugs on nuclear hormone receptors (NHRs) may result in adverse
effects in multiple organs/physiological processes. Reliable assessments of the NHR …

A quantitative biometrological assessment of acne and hormonal evaluation in young women using a triphasic low-dose oral contraceptive containing gestodene

C Piérard-Franchimont, U Gaspard… - … European Journal of …, 2000 - Taylor & Francis
Objective To investigate the effect of a triphasic low-dose oral contraceptive pill containing
gestodene on acne severity and hormone levels in young women over 13 menstrual cycles …

Clinical comparison of monophasic oral contraceptive preparations of gestodene/ethinyl estradiol and desogestrel/ethinyl estradiol

Latin American Oral Contraceptive Study Group - Contraception, 1994 - Elsevier
The efficacy, cycle control, subjective complaints, and safety of monophasic preparations of
the oral contraceptives containing gestodene 75 mcg plus ethinyl estradiol 30 mcg versus …

Benefits and risks of oral contraceptive use

RS Williams - Postgraduate medicine, 1992 - Taylor & Francis
Preview Oral contraceptives do more than prevent pregnancy. Estrogen lowers the risk of
ovarian cancer and cysts, and progestin lowers the risk of endometrial cancer. However …

Inhibition of ovulation by low-dose monophasic contraceptive containing gestodene

K Thomas, L Vankrieken - American journal of obstetrics and gynecology, 1990 - Elsevier
Ovulation inhibition by the monophasic oral contraceptive containing 75 μg of gestodene
and 30 wg of ethinyl estradiol was evaluated in 25 healthy volunteers for five cycles: a …

Clinical and metabolic effects of a pill containing 30 mcg ethinylestradiol plus 75 mcg gestodene

P Fioretti, F Fruzzetti, R Navalesi, C Ricci, R Miccoli… - Contraception, 1989 - Elsevier
The clinical and metabolic effects of a short-term treatment with a combination contraceptive
pill containing 30 mcg ethinylestradiol and 75 mcg gestodene were evaluated in a group of …

Clinical and metabolic effects of a triphasic pill containing gestodene

F Fruzzetti, C Ricci, I Nicoletti, P Fioretti - Contraception, 1992 - Elsevier
The clinical and metabolic effects of a low-dose triphasic oral contraceptive containing
gestodene were investigated in 42 healthy women during 6 months of treatment. No …