This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

COVID-19 is a disease with unique characteristics that include lung thrombosis, frequent
diarrhoea, abnormal activation of the inflammatory response and rapid deterioration of lung …

In autosomal dominant polycystic kidney disease (ADPKD) multiple bilateral renal cysts
gradually enlarge, leading to a decline in renal function. Transepithelial chloride secretion …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory
chloride/bicarbonate channel in airways and intestine that is activated through ATP binding …

The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

TMEM16A (known as anoctamin 1) Ca 2+-activated chloride channel is overexpressed in
many tumors. TMEM16A overexpression can be caused by gene amplification in many …

ABSTRACT Transmembrane member 16A (TMEM16A) is the Ca2+‐activated chloride
channel in airways and intestine. It has been associated with goblet cell metaplasia, as …

TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐
activated chloride channels, with ten transmembrane segments. Recently, atomic structures …