Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer

N Li, X Zhang, J Zhou, W Li, X Shu, Y Wu… - Advanced Drug Delivery …, 2022 - Elsevier
A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

How the mechanical microenvironment of stem cell growth affects their differentiation: A review

X Zhang, S Zhang, T Wang - Stem cell research & therapy, 2022 - Springer
Stem cell differentiation is of great interest in medical research; however, specifically and
effectively regulating stem cell differentiation is still a challenge. In addition to chemical …

Bone regeneration and oxidative stress: an updated overview

AE Bădilă, DM Rădulescu, A Ilie, AG Niculescu… - Antioxidants, 2022 - mdpi.com
Bone tissue engineering is a complex domain that requires further investigation and benefits
from data obtained over past decades. The models are increasing in complexity as they …

[HTML][HTML] Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

H Shi, K Zhou, M Wang, N Wang, Y Song, W Xiong… - Theranostics, 2023 - ncbi.nlm.nih.gov
Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

In vitro functional models for human liver diseases and drug screening: beyond animal testing

A Paradiso, M Volpi, C Rinoldi, N Celikkin… - Biomaterials …, 2023 - pubs.rsc.org
Liver is one of the most important and complex organs in the human body, being
characterized by a sophisticated microarchitecture and responsible for key physiological …

Synthesis of ZnO nanoparticles on carbon graphite and its application as a highly efficient electrochemical nano-sensor for the detection of amoxicillin: analytical …

J Zoubir, I Bakas, A Assabbane - Nanotechnology for Environmental …, 2021 - Springer
Amoxicillin is an antimicrobial of the penicillin class discovered in 1928. The objective of this
paper is to construct a simple platform for electrocatalytic detection of amoxicillin using a …

A biomimetic renal fibrosis progression model on-chip evaluates anti-fibrotic effects longitudinally in a dynamic fibrogenic niche

D Wu, J Wu, H Liu, S Shi, L Wang, Y Huang, X Yu… - Lab on a Chip, 2023 - pubs.rsc.org
Although renal fibrosis can advance chronic kidney disease and progressively lead to end-
stage renal failure, no effective anti-fibrotic drugs have been clinically approved. To aid drug …

Assessment of human embryonic stem cells differentiation into definitive endoderm lineage on the soft substrates

JK Virdi, P Pethe - Cell Biology International, 2024 - Wiley Online Library
Pluripotent stem cells (PSCs) hold enormous potential for treating multiple diseases owing
to their ability to self‐renew and differentiate into any cell type. Albeit possessing such …

[HTML][HTML] Biophysical cues involved in the stem cell niche for stemness maintenance

C Li, L Zheng, Y Fan - Medicine in Novel Technology and Devices, 2024 - Elsevier
The characteristics of stem cells are self-renewal ability and differentiation potential. These
properties are defined as stemness, offering them application in tissue repair and …

Fluid Flow Mechanical Stimulation-Assisted Cartridge Device for the Osteogenic Differentiation of Human Mesenchymal Stem Cells

KT Lim, DK Patel, SD Dutta, K Ganguly - Micromachines, 2021 - mdpi.com
Human mesenchymal stem cells (hMSCs) have the potential to differentiate into different
types of mesodermal tissues. In vitro proliferation and differentiation of hMSCs are …