ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …

Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

Background Intervertebral disc degeneration (IVDD) is considered a multifactorial disease
that is influenced by both environmental and genetic factors. The last two decades of …

The global aging population has led to an increase in geriatric diseases, including adult
degenerative scoliosis (ADS). ADS is a spinal deformity affecting adults, particularly females …

Summary A Disintegrin And Metalloproteinase with ThromboSpondin motif (ADAMTS)‐5
was identified in 1999 as one of the enzymes responsible for cleaving aggrecan, the major …

The RUNX2 transcription factor is a key regulator for the development of cartilage and bone.
Global or resting chondrocyte-specific deletion of the Runx2 gene results in failure of …

(1) Background: The purpose of this review is to analyze domestic and foreign studies on the
role of collagen-encoding genes polymorphism in the development of intervertebral discs …

Abstract Purpose of Review This review aims to highlight recent advances in understanding
the genetic basis of intervertebral disc degeneration (IDD). Recent Findings It has been …

The relationship between various factors predisposing to the formation of spondylolisthesis,
including degenerative spondylolisthesis, has been analyzed by many authors. However …

The aim of this study is to investigate the expression levels of genome-wide association
studies (GWAS)-identified variants near Gasdermin-C (GSDMC) and its association with …