Genetics and the causes of ankylosing spondylitis
Genetic studies of ankylosing spondylitis (AS) have, over the past decade, provided major
insights into the etiopathogenesis of the disease that have led to major therapeutic …
insights into the etiopathogenesis of the disease that have led to major therapeutic …
[HTML][HTML] Preparing unbiased T-cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling
IZ Mamedov, OV Britanova, IV Zvyagin… - Frontiers in …, 2013 - frontiersin.org
High-throughput sequencing has the power to reveal the nature of adaptive immunity as
represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but …
represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but …
[HTML][HTML] Optimized peptide–MHC multimer protocols for detection and isolation of autoimmune T-cells
Peptide–MHC (pMHC) multimers have become the “gold standard” for the detection and
isolation of antigen-specific T-cells but recent evidence shows that normal use of these …
isolation of antigen-specific T-cells but recent evidence shows that normal use of these …
Quantitative profiling of immune repertoires for minor lymphocyte counts using unique molecular identifiers
ES Egorov, EM Merzlyak, AA Shelenkov… - The Journal of …, 2015 - journals.aai.org
Emerging high-throughput sequencing methods for the analyses of complex structure of
TCR and BCR repertoires give a powerful impulse to adaptive immunity studies. However …
TCR and BCR repertoires give a powerful impulse to adaptive immunity studies. However …
Quantitative tracking of T cell clones after haematopoietic stem cell transplantation
IZ Mamedov, OV Britanova, DA Bolotin… - EMBO molecular …, 2011 - embopress.org
Autologous haematopoietic stem cell transplantation is highly efficient for the treatment of
systemic autoimmune diseases, but its consequences for the immune system remain poorly …
systemic autoimmune diseases, but its consequences for the immune system remain poorly …
Survivin; a novel therapeutic target that correlates with survival of autoreactive T lymphocytes obtained from patients with ankylosing spondylitis
Ankylosing spondylitis (AS) is progressive immune-mediated arthritis. Persistent
autoreactivity of T cells with an up-regulated Survivin expression is strongly implicated in AS …
autoreactivity of T cells with an up-regulated Survivin expression is strongly implicated in AS …
[HTML][HTML] Juvenile spondyloarthritis: what more do we know about HLA-B27, enthesitis, and new bone formation?
Juvenile spondyloarthritis (JSpA) refers to a diverse spectrum of immune-mediated
inflammatory arthritides whose onset occurs in late childhood and adolescence. Like its …
inflammatory arthritides whose onset occurs in late childhood and adolescence. Like its …
Characterization of peripheral blood TCR repertoire in patients with ankylosing spondylitis by high-throughput sequencing
JH Cui, Y Jin, KR Lin, P Xiao, X Chen, Y Pan, W Lin… - Human Immunology, 2018 - Elsevier
Ankylosing spondylitis (AS) is a chronic and progressive autoimmune disease affecting the
invasion of the spine, sacroiliac joints and peripheral joints. T cells play a vital role in the …
invasion of the spine, sacroiliac joints and peripheral joints. T cells play a vital role in the …
Higher frequency of peripheral blood interleukin 21 positive follicular helper T cells in patients with ankylosing spondylitis
F Xiao, HY Zhang, YJ Liu, D Zhao, YX Shan… - The Journal of …, 2013 - jrheum.org
Objective. The role of follicular Th (TFH) cells remains unclear in the pathogenesis of
ankylosing spondylitis (AS). Our study examined the frequency of different subsets of …
ankylosing spondylitis (AS). Our study examined the frequency of different subsets of …