Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC
has progressed from initial discoveries which focused on the stepwise accumulation of key …

The Warburg effect and its accompanying metabolic features (anaplerosis, cataplerosis) are
presented in textbooks and reviews as a hallmark (general characteristic): the metabolic …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Quantification of the effect of spatial tumour sampling on the patterns of mutations detected
in next-generation sequencing data is largely lacking. Here we use a spatial stochastic …

Aggressive NK-cell leukemia (ANKL) is a rare form of NK cell neoplasm that is more
prevalent among people from Asia and Central and South America. Patients usually die …

Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis
represents canonical type I programmed cell death. Autophagy is viewed as pro-survival …

Hepatocellular carcinoma (HCC) is characterized by high heterogeneity in both intratumoral
and interpatient manners. While interpatient heterogeneity is related to personalized …

Although tumorigenesis has been accepted as an evolutionary process (,), many forces may
operate differently in cancers than in organisms, as they evolve at vastly different time …

The interactions between tumor and immune cells along the course of breast cancer
progression remain largely unknown. Here, we extensively characterize multiple sequential …

Cancer is a serious health problem with a high mortality rate worldwide. Given the relevance
of mitochondria in numerous physiological and pathological mechanisms, such as …