Scalable reinforcement-learning-based neural architecture search for cancer deep learning research
Cancer is a complex disease, the understanding and treatment of which are being aided
through increases in the volume of collected data and in the scale of deployed computing …
through increases in the volume of collected data and in the scale of deployed computing …
Personalized treatment for hepatocellular carcinoma: Current status and future perspectives
Systemic treatment for hepatocellular carcinoma (HCC) has been advancing rapidly over the
last decade. More novel agents, including both targeted agents and immune checkpoint …
last decade. More novel agents, including both targeted agents and immune checkpoint …
Engineering chimeric antigen receptor-T cells for cancer treatment
Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in
cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently, chimeric …
cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently, chimeric …
[HTML][HTML] Multiregional tumor trees are not phylogenies
Tumor samples most often comprise a mixture of different cell lineages. Multiregional trees
built from bulk mutational profiles do not consider this heterogeneity and can potentially lead …
built from bulk mutational profiles do not consider this heterogeneity and can potentially lead …
Epimutations define a fast-ticking molecular clock in plants
N Yao, RJ Schmitz, F Johannes - Trends in Genetics, 2021 - cell.com
Stochastic gains and losses of DNA methylation at CG dinucleotides are a frequent
occurrence in plants. These spontaneous 'epimutations' occur at a rate that is 100 000 times …
occurrence in plants. These spontaneous 'epimutations' occur at a rate that is 100 000 times …
[HTML][HTML] Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy
We consider a system of two coupled integro-differential equations modelling populations of
healthy and cancer cells under chemotherapy. Both populations are structured by a …
healthy and cancer cells under chemotherapy. Both populations are structured by a …
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
The type and genomic context of cancer mutations depend on their causes. These causes
have been characterized using signatures that represent mutation types that co-occur in the …
have been characterized using signatures that represent mutation types that co-occur in the …
Natural selection in cancer biology: from molecular snowflakes to trait hallmarks
Evolution by natural selection is the conceptual foundation for nearly every branch of biology
and increasingly also for biomedicine and medical research. In cancer biology, evolution …
and increasingly also for biomedicine and medical research. In cancer biology, evolution …
The global relationship between chromatin physical topology, fractal structure, and gene expression
LM Almassalha, A Tiwari, PT Ruhoff, Y Stypula-Cyrus… - Scientific reports, 2017 - nature.com
Most of what we know about gene transcription comes from the view of cells as molecular
machines: focusing on the role of molecular modifications to the proteins carrying out …
machines: focusing on the role of molecular modifications to the proteins carrying out …
Two-phased evolution: Genome chaos-mediated information creation and maintenance
Cancer is traditionally labeled a “cellular growth problem.” However, it is fundamentally an
issue of macroevolution where new systems emerge from tissue by breaking various …
issue of macroevolution where new systems emerge from tissue by breaking various …