The CRISPR–Cas9 system is a powerful tool for genome editing, which allows the precise
modification of specific DNA sequences. Many efforts are underway to use the CRISPR …

ABSTRACT A major impediment to successful use of therapeutic protein drugs is their ability
to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a …

Protein therapeutics hold a prominent role and have brought significant diversity in
efficacious medicinal products. Not just monoclonal antibodies and different antibody …

We report significant upregulation of Galectin-9 (Gal-9) and VISTA on both CD4+ and CD8+
T cells in HIV-infected human patients. Gal-9 and VISTA expression was associated with …

CD4+ T cells comprise multiple functionally distinct cell populations that play a key role in
immunity. Despite blood monitoring of CD4+ T-cell subsets is of potential clinical utility, no …

Analysis of T lymphocyte proliferation and activation after antigenic or mitogenic stimulation
is a vital parameter used in the diagnosis of various immuno-deficiencies and during the …

We introduce a new method for single-cell cytometry studies, FAUST, which performs
unbiased cell population discovery and annotation. FAUST processes experimental data on …

Background Merkel cell carcinoma (MCC) often responds to PD-1 pathway blockade,
regardless of tumor-viral status (~ 80% of cases driven by the Merkel cell polyomavirus …

In Italy, from January 2021, the Ministry of Health indicated a vaccination plan against
COVID for frail patients and physicians based on a three-dose scheme. However, conflicting …

CD4+ T cells are crucial in cytomegalovirus (CMV) infection, but their role in infection
remains unclear. The heterogeneity and potential functions of CMVpp65-reactivated CD4+ T …