Successful development of treatments for non-alcoholic fatty liver disease and its
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …

Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

Abstract The pathophysiology of Non-Alcoholic Steatohepatitis (NASH) encompasses a
complex set of intra-and extrahepatic driving mechanisms, involving numerous metabolic …

Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation
process consisting in altered deposition of extracellular matrix. Progression of fibrosis can …

Non-alcoholic steatohepatitis (NASH) represents a global health concern. It is characterised
by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity …

The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …

Background Disturbed bile acid homeostasis may foster development of short bowel
syndrome (SBS) associated liver disease during and after weaning off parenteral nutrition …

Chronic hepatic diseases often compromise liver function and are directly responsible for up
to two million yearly deaths world-wide. There are yet no treatment options to solve this …

Wilson disease (WD) is a metabolic disorder caused by inactivation of the copper-
transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu causes …

Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic
steatosis, inflammation, and progressive fibrosis. Our previous study demonstrated that …