[HTML][HTML] Pulmonary complications after pediatric stem cell transplant

T Fitch, KC Myers, M Dewan, C Towe… - Frontiers in …, 2021 - frontiersin.org
The number of disorders that benefit from hematopoietic stem cell transplantation (HSCT)
has increased, causing the overall number of HSCT to increase accordingly. Disorders …

[HTML][HTML] Crosstalk between intestinal microbiota derived metabolites and tissues in allogeneic hematopoietic cell transplantation

H Fujiwara - Frontiers in immunology, 2021 - frontiersin.org
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an evidence based-
cellular immunotherapy for hematological malignancies. Immune reactions not only promote …

Respiratory viruses in hematopoietic cell transplant candidates: impact of preexisting lower tract disease on outcomes

YJ Kim, A Waghmare, H Xie, L Holmberg… - Blood …, 2022 - ashpublications.org
Pretransplant respiratory virus infections (RVIs) have been shown to negatively affect
hematopoietic cell transplantation (HCT) outcomes. The impact of and need for delay of HCT …

[HTML][HTML] Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation

MS Zinter, CC Dvorak, MY Mayday, G Reyes… - Nature Medicine, 2024 - nature.com
Hematopoietic cell transplantation (HCT) uses cytotoxic chemotherapy and/or radiation
followed by intravenous infusion of stem cells to cure malignancies, bone marrow failure and …

Commensal Oral Microbiota, Disease Severity, and Mortality in Fibrotic Lung Disease

DN O'Dwyer, JS Kim, SF Ma, P Ranjan… - American Journal of …, 2024 - atsjournals.org
Rationale: Oral microbiota associate with diseases of the mouth and serve as a source of
lung microbiota. However, the role of oral microbiota in lung disease is unknown. Objectives …

The use and duration of preintubation respiratory support is associated with increased mortality in immunocompromised children with acute respiratory failure

RB Lindell, JC Fitzgerald, CM Rowan… - Critical care …, 2022 - journals.lww.com
OBJECTIVES: To determine the association between preintubation respiratory support and
outcomes in patients with acute respiratory failure and to determine the impact of …

[HTML][HTML] HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant

JA Hill, YJ Lee, LK Vande Vusse, H Xie… - Nature …, 2024 - nature.com
Limited understanding of the immunopathogenesis of human herpesvirus 6B (HHV-6B) has
prevented its acceptance as a pulmonary pathogen after hematopoietic cell transplant …

Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates

MS Zinter, AB Versluys, CA Lindemans… - Science translational …, 2022 - science.org
Impaired baseline lung function is associated with mortality after pediatric allogeneic
hematopoietic cell transplantation (HCT), yet limited knowledge of the molecular pathways …

The Lung Microbiome

JH Lipinksi, P Ranjan, RP Dickson… - The Journal of …, 2024 - journals.aai.org
Although the lungs were once considered a sterile environment, advances in sequencing
technology have revealed dynamic, low-biomass communities in the respiratory tract, even …

Novel approaches to the prediction and diagnosis of pulmonary complications in the paediatric haematopoietic stem cell transplant patient

H Walker, S Shanthikumar, T Cole… - Current Opinion in …, 2022 - journals.lww.com
Pulmonary infectious complications post HSCT remain a devastating complication for
children and their families. Despite improvements in standard and novel diagnostic …