Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens
RA Quinlan, JI Clark - Journal of Biological Chemistry, 2022 - ASBMB
In the human eye, a transparent cornea and lens combine to form the" refracton" to focus
images on the retina. This requires the refracton to have a high refractive index" n," mediated …
images on the retina. This requires the refracton to have a high refractive index" n," mediated …
Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …
bidirectional transport of water across biological membranes in response to osmotic …
Heterogeneous synthetic vesicles toward artificial cells: engineering structure and composition of membranes for multimodal functionalities
The desire to develop artificial cells to imitate living cells in synthetic vesicle platforms has
continuously increased over the past few decades. In particular, heterogeneous synthetic …
continuously increased over the past few decades. In particular, heterogeneous synthetic …
[HTML][HTML] Age-related changes in eye lens biomechanics, morphology, refractive index and transparency
Life-long eye lens function requires an appropriate gradient refractive index, biomechanical
integrity and transparency. We conducted an extensive study of wild-type mouse lenses 1 …
integrity and transparency. We conducted an extensive study of wild-type mouse lenses 1 …
Environmentally relevant concentrations of F–53B induce eye development disorders-mediated locomotor behavior in zebrafish larvae
L Wu, M Zeeshan, Y Dang, LY Liang, YC Gong, QQ Li… - Chemosphere, 2022 - Elsevier
The perfluorooctane sulfonate alternative, F–53B, induces multiple physiological defects but
whether it can disrupt eye development is unknown. We exposed zebrafish to F–53B at four …
whether it can disrupt eye development is unknown. We exposed zebrafish to F–53B at four …
Lens aquaporins function as peroxiporins to facilitate membrane transport of hydrogen peroxide
K Varadaraj, SS Kumari - Biochemical and biophysical research …, 2020 - Elsevier
High levels of reactive oxygen species such as hydrogen peroxide (H 2 O 2) cause oxidative
stress in the lens and lead to cataractogenesis. The present investigation was undertaken to …
stress in the lens and lead to cataractogenesis. The present investigation was undertaken to …
Fibronectin has multifunctional roles in posterior capsular opacification (PCO)
MH Shihan, M Kanwar, Y Wang, EE Jackson… - Matrix Biology, 2020 - Elsevier
Fibrotic posterior capsular opacification (PCO), one of the major complications of cataract
surgery, occurs when lens epithelial cells (LCs) left behind post cataract surgery (PCS) …
surgery, occurs when lens epithelial cells (LCs) left behind post cataract surgery (PCS) …
Physiological mechanisms regulating lens transport
AA Giannone, L Li, C Sellitto, TW White - Frontiers in Physiology, 2021 - frontiersin.org
The transparency and refractive properties of the lens are maintained by the cellular
physiology provided by an internal microcirculation system that utilizes spatial differences in …
physiology provided by an internal microcirculation system that utilizes spatial differences in …
Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors
Z Amro, LE Collins-Praino, AJ Yool - Bioscience Reports, 2024 - portlandpress.com
In addition to aquaporin (AQP) classes AQP1, AQP4 and AQP9 known to be expressed in
mammalian brain, our recent transcriptomic analyses identified AQP0 and AQP11 in human …
mammalian brain, our recent transcriptomic analyses identified AQP0 and AQP11 in human …
Whole exome sequencing of 20 Spanish families: candidate genes for non-syndromic pediatric cataracts
P Rodríguez-Solana, N Arruti… - International Journal of …, 2023 - mdpi.com
Non-syndromic pediatric cataracts are defined as opacification of the crystalline lens that
occurs during the first years of life without affecting other organs. Given that this disease is …
occurs during the first years of life without affecting other organs. Given that this disease is …