Biodegradable synthetic polymers: Preparation, functionalization and biomedical application
Biodegradable polymers have been widely used and have greatly promoted the
development of biomedical fields because of their biocompatibility and biodegradability. The …
development of biomedical fields because of their biocompatibility and biodegradability. The …
Gene therapy and DNA delivery systems
Gene therapy is a promising new technique for treating many serious incurable diseases,
such as cancer and genetic disorders. The main problem limiting the application of this …
such as cancer and genetic disorders. The main problem limiting the application of this …
Dendrimers in gene delivery
C Dufès, IF Uchegbu, AG Schätzlein - Advanced drug delivery reviews, 2005 - Elsevier
Dendrimers have unique molecular architectures and properties that make them attractive
materials for the development of nanomedicines. Key properties such as defined …
materials for the development of nanomedicines. Key properties such as defined …
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
M Morille, C Passirani, A Vonarbourg, A Clavreul… - Biomaterials, 2008 - Elsevier
Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its
potential role in the treatment of acquired diseases such as cancer is now widely …
potential role in the treatment of acquired diseases such as cancer is now widely …
Inorganic nanoparticles as carriers of nucleic acids into cells
V Sokolova, M Epple - Angewandte chemie international …, 2008 - Wiley Online Library
The transfer of nucleic acids (DNA or RNA) into living cells, that is, transfection, is a major
technique in current biochemistry and molecular biology. This process permits the selective …
technique in current biochemistry and molecular biology. This process permits the selective …
Polymers for gene delivery across length scales
D Putnam - Nature materials, 2006 - nature.com
A number of human diseases stem from defective genes. One approach to treating such
diseases is to replace, or override, the defective genes with normal genes, an approach …
diseases is to replace, or override, the defective genes with normal genes, an approach …
[PDF][PDF] Vectors and delivery systems in gene therapy
Gene therapy provides modern medicine with new perspectives that were unthinkable two
decades ago. Progress in molecular biology and, especially, molecular medicine is now …
decades ago. Progress in molecular biology and, especially, molecular medicine is now …
Gene delivery with synthetic (non viral) carriers
MD Brown, AG Schätzlein, IF Uchegbu - International Journal of …, 2001 - Elsevier
Non-viral gene delivery involving the use of cationic polymer and cationic lipid based
carriers still continues to enjoy a high profile due to the safety advantages offered by these …
carriers still continues to enjoy a high profile due to the safety advantages offered by these …
Plasmid copy number and plasmid stability
K Friehs - New trends and developments in biochemical …, 2004 - Springer
Many expression systems in research and industry use plasmids as vectors for the
production of recombinant proteins or non-proteinous recombinant substances. Plasmids …
production of recombinant proteins or non-proteinous recombinant substances. Plasmids …
Poly(l-lysine)-Modified Iron Oxide Nanoparticles for Stem Cell Labeling
M Babic, D Horák, M Trchová, P Jendelová… - Bioconjugate …, 2008 - ACS Publications
New surface-modified iron oxide nanoparticles were developed by precipitation of Fe (II)
and Fe (III) salts with ammonium hydroxide and oxidation of the resulting magnetite with …
and Fe (III) salts with ammonium hydroxide and oxidation of the resulting magnetite with …