Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

Chronic inflammation impairs skeletal muscle regeneration. Although many cells are
involved in chronic inflammation, macrophages seem to play an important role in impaired …

Slower, more oxidative muscle fibers are more resistant to the dystrophic pathology in
Duchenne muscular dystrophy (DMD) patients as well as in the preclinical mdx mouse …

Autophagy is a conserved cellular process for degrading aggregate proteins and
dysfunctional organelle. It is still debatable if autophagy and mitophagy (a specific process …

Background Volumetric muscle loss (VML) injuries occur due to orthopaedic trauma or the
surgical removal of skeletal muscle and result in debilitating long-term functional deficits …

Duchenne muscular dystrophy (DMD) is a life‐limiting, neuromuscular disorder that causes
progressive, severe muscle wasting in boys and young men. Although there is no cure …

Volumetric muscle loss (VML) injuries represent a majority of military service member
casualties and are common in civilian populations following blunt and/or penetrating …

Estradiol deficiency in females can result in skeletal muscle strength loss, and treatment with
estradiol mitigates the loss. There are three primary estrogen receptors (ERs), and estradiol …

Menopause is associated with declines in physical activity and skeletal muscle strength.
Physical activity is also reduced in rodents after ovariectomy (OVX) and whole-body …

Introduction: Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by a
dystrophin protein deficiency. Dystrophin functions to stabilize and protect the muscle fiber …