LncRNA SNHG15: A potential therapeutic target in the treatment of colorectal cancer

MO Olatubosun, MB Abubakar… - Chemical Biology & …, 2023 - Wiley Online Library
The global burden of colorectal cancer (CRC) is increasing annually. CRC could develop
from genetic and phenotypic factors involving changes in gene expression. Incredibly, the …

[HTML][HTML] SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal …

M Saeinasab, AR Bahrami, J González… - Journal of Experimental …, 2019 - Springer
Background Thousands of long noncoding RNAs (lncRNAs) are aberrantly expressed in
various types of cancers, however our understanding of their role in the disease is still very …

[HTML][HTML] GADD45A plays a protective role against temozolomide treatment in glioblastoma cells

HH Wang, TY Chang, WC Lin, KC Wei, JW Shin - Scientific reports, 2017 - nature.com
Glioblastoma multiforme (GBM) is one of the most aggressive cancers. Despite recent
advances in multimodal therapies, high-grade glioma remains fatal. Temozolomide (TMZ) is …

Identification of small molecule inhibitors of p27Kip1 ubiquitination by high‐throughput screening

LC Ooi, N Watanabe, Y Futamura, SF Sulaiman… - Cancer …, 2013 - Wiley Online Library
Dysregulation of p27Kip1 due to proteolysis that involves the ubiquitin ligase (SCF) complex
with S‐phase kinase‐associated protein 2 (S kp2) as the substrate‐recognition component …

[HTML][HTML] Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways …

J Krushkal, Y Zhao, C Hose, A Monks, JH Doroshow… - Clinical …, 2016 - Springer
Background Aberrant patterns of DNA methylation are abundant in cancer, and epigenetic
pathways are increasingly being targeted in cancer drug treatment. Genetic components of …

Agrochemicals related to maize crops in South Africa and associated biological effects: an in vitro study

I Horak - 2023 - repository.nwu.ac.za
Although agrochemicals reduce pest-associated crop losses, these chemicals end up in non-
target environments following rainfall and irrigation. When fractions of agrochemical …