We derive some exact general results concerning the behavior of topological absorbers (ie,
sequences undergoing topologically driven structural transitions) in closed circular DNA …

The transcriptional outputs of genes are often dependent on their chromosomal
localizations. Such positional effects suggest that the architecture of chromatin structures …

The porphyrin–DNA binding modes depend on both the structural properties of the
porphyrinoid derivatives and the DNA sequences and conformations. The experimental …

The precise regulation of PDGFR-β activity and expression is essential for mammalian
development and maintenance of homeostasis in the adult [1-3]. Aberrant expression that …

Transcription by RNA polymerase can induce the formation of hypernegatively supercoiled
DNA both in vivo and in vitro. This phenomenon has been explained by a “twin-supercoiled …

Readout of eukaryotic genomes is soft-wired, leading to many different messages from a
single gene. Z-DNA and double-stranded RNA (dsRNA) are both examples where genetic …

We deduced the torque applied on a single stretched and twisted DNA by integrating with
respect to force the change in the molecule's extension as it is coiled. While consistent with …

With recent advances in sequencing and mapping of genomes, the occurrence of
overlapping and nested transcription units is more common than previously thought in both …

In the cell, nearly 40% of the volume is occupied by macromolecular crowding agents and
smaller osmolytes that accumulate in response to environmental stresses. The effects of …

Biological systems are remarkably precise in a lot of different ways. Not only do organisms
have the capacity to reproduce, they also have the capacity to defend themselves from …