It is well known that F-actin dynamics drive the micron-scale cell shape changes required for
migration and immunological synapse (IS) formation. In addition, recent evidence points to a …

Large-scale molecular assemblies, or signaling clusters, at the cell membrane are emerging
as important regulators of cell signaling. Here, we review new findings and describe shared …

Integrity of the dendritic cell (DC) actin cytoskeleton is essential for T cell priming, but the
underlying mechanisms are poorly understood. We show that the DC F-actin network …

A series of novel chemically defined soluble oligomers of the human MHC class II protein
HLA-DR1 was constructed to probe the molecular requirements for initiation of T cell …

Exosomes secreted by dendritic cells (DCs) contain MHC-I, MHC-II, and other accessory
molecules required for antigen presentation to T cells. Previous studies have shown that …

At the interface between T cell and antigen-presenting cell (APC), peptide antigen presented
by MHC (pMHC) binds to the T cell receptor (TCR) and initiates signaling. The mechanism of …

T cells play a major role in adaptive immune response, and T cell dysfunction can lead to the
progression of several diseases that are often associated with changes in the mechanical …

Type 1 diabetes is an organ-specific autoimmune disease that is mediated by autoreactive T
cells. We show here that administration of a soluble dimeric peptide–major histocompatibility …

T cells are activated via engagement of their cell-surface receptors with molecules of the
major histocompatibility complex (MHC) displayed on another cell surface. This process …

Through T cell receptors (TCRs), T cells can detect and respond to very small numbers of
foreign peptides among a huge number of self-peptides presented by major …