Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Splicing factor poly (rC)‐binding protein 1 is a novel and distinctive tumor suppressor

J Guo, R Jia - Journal of cellular physiology, 2019 - Wiley Online Library
A lot of evidence has been found on the link between tumorigenesis and the aberrant
expression of splicing factors. A number of splicing factors have been reported to be either …

[HTML][HTML] Advances in poly (rC)-binding protein 2: Structure, molecular function, and roles in cancer

C Yuan, M Chen, X Cai - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract Poly (rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized
by its ability to interact with poly (C) with high affinity in a sequence-specific manner. PCBP2 …

LINC02535 co‐functions with PCBP2 to regulate DNA damage repair in cervical cancer by stabilizing RRM1 mRNA

D Wen, Z Huang, Z Li, X Tang, X Wen… - Journal of Cellular …, 2020 - Wiley Online Library
Cervical cancer (CC) is one of the commonest malignant cancers among women with high
morbidity and mortality. Despite encouraging advances had been found in diagnostic and …

[HTML][HTML] Iron as spirit of life to share under monopoly

S Toyokuni, Y Kong, H Zheng, Y Maeda… - Journal of Clinical …, 2022 - ncbi.nlm.nih.gov
Any independent life requires iron to survive. Whereas iron deficiency causes oxygen
insufficiency, excess iron is a risk for cancer, generating a double-edged sword. Iron …

[HTML][HTML] PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions

T Ishii, T Igawa, H Hayakawa, T Fujita… - Journal of Biological …, 2020 - ASBMB
PCBP1, a member of the poly (C)-binding protein (PCBP) family, has the capability of
binding heavily oxidized RNA and therefore participates in the cellular response to oxidative …

[HTML][HTML] LIMD2 is a Prognostic and Predictive Marker in Patients With Esophageal Cancer Based on a ceRNA Network Analysis

Y Chen, X Huang, K Zhu, C Li, H Peng, L Chen… - Frontiers in …, 2021 - frontiersin.org
Globally, esophageal cancer (ECA) is the seventh most common cancer and sixth most
common cause of cancer-associated mortality. However, there are no reliable prognostic …

[HTML][HTML] Systematic profiling of a novel prognostic alternative splicing signature in hepatocellular carcinoma

D Zhang, Y Duan, Z Wang, J Lin - Oncology Reports, 2019 - spandidos-publications.com
Alternative splicing (AS) is a pervasive and vital mechanism involved in the progression of
cancer by expanding genomic encoding capacity and increasing protein complexity …

[HTML][HTML] Silencing of α-complex protein-2 reverses alcohol-and cytokine-induced fibrogenesis in hepatic stellate cells

H Liu, Z Chen, W Jin, A Barve, YJY Wan, K Cheng - Liver research, 2017 - Elsevier
Background and aim α-complex protein-2 (αCP2) encoded by the poly (rC) binding protein 2
(PCBP2) gene is responsible for the accumulation of type I collagen in fibrotic livers. In this …

Role of miR‐490‐3p in blocking bladder cancer growth through targeting the RNA‐binding protein PCBP2

CM Zhang, LD Song, JW Wang… - The Kaohsiung journal …, 2022 - Wiley Online Library
Abstract MiR‐490‐3p is regarded as a tumor suppressor in many cancers, but whether miR‐
490‐3p is involved in the development of bladder cancer remains unknown. BALB/c nude …