The human placenta has a number of protective mechanisms that help to prevent potentially
harmful compounds from entering the fetal compartment. Two important transporter proteins …

ABSTRACT MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in
bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three …

P‐glycoprotein, encoded by ABCB 1, is an ATP‐dependent drug efflux pump which exports
substances outside the cell. Some studies described connections between C3435T …

Sertraline is a selective serotonin reuptake inhibitor widely metabolized in the liver by
cytochrome P450 (CYP) enzymes. Besides, it is a P‐glycoprotein substrate. Moreover …

In the last decade, the onset of neurodegenerative (ND) diseases is strongly widespread
due to the age increase of the world population. Despite the intensive investigations boosted …

ABCG2 belongs to the ABC transporter superfamily and functions as a poly‐specific efflux
pump. As it can transport a broad spectrum of substrates out of cells, ABCG2 is thought to …

Adenosine triphosphate-binding cassette (ABC)-type transport proteins were initially
described for their ability to reduce intracellular concentrations of anti-cancer compounds …

Introduction: Members of the ATP-binding cassette (ABC) transmembrane transporters
control the passage of several substrates across cell membranes, including drugs. This …

Aflatoxins, ochratoxins, and citrinin commonly occur naturally in the environment and
contaminate food/feed. The prevalence of aflatoxins is greater in Africa and Southeast Asia …

Objective ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-
glycoprotein, is an efflux protein implicated in the absorption and the distribution of various …