Traumatic brain injury (TBI), as a serious central nervous system disease, can result in
severe neurological dysfunction or even disability and death of patients. The early and …

Cerebral small vessel disease (CSVD) is one of the most important causes of stroke and
vascular dementia, so exploring effective treatment modalities for CSVD is warranted. This …

Oxidative stress and neuroinflammation are two major causes leading to early brain injury
after subarachnoid hemorrhage (SAH). Nuclear factor E2-related factor 2 (Nrf2) is a critical …

Background Mitochondrial dysregulation in skeletal myocytes is considered a major factor in
aged sarcopenia. In this study, we aimed to study the effects of peroxisome proliferator …

Sestrin2 is a highly conserved protein that can be induced under various stress conditions.
Researches have revealed that the signaling pathway of the mammalian target of rapamycin …

Polygonum sibiricum, with its medicinal and edibility dual properties, has been widely
recognized and utilized throughout Chinese history. As a kind of its effective component …

Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated
encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a …

Background Sestrin2 is a highly conserved stress-inducible protein with neuroprotective
properties. Herein, we investigated the prognostic significance of serum sestrin2 in human …

Most central nervous diseases are accompanied by astrocyte activation. Autophagy, an
important pathway for cells to protect themselves and maintain homeostasis, is widely …

Purpose To explore the correlation of endoplasmic reticulum stress (ERS) and oxidative
stress (OS), and the protective effect of Sestrin2 (SESN2) on human lens epithelial cells …