Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway
Y Zhou, Y Zhang, BOA Botchway, M Huang… - Metabolic Brain Disease, 2024 - Springer
Traumatic brain injury (TBI), as a serious central nervous system disease, can result in
severe neurological dysfunction or even disability and death of patients. The early and …
severe neurological dysfunction or even disability and death of patients. The early and …
Edaravone dexborneol ameliorates cognitive impairment by regulating the NF-κB pathway through AHR and promoting microglial polarization towards the M2 …
L Li, G He, M Shi, J Zhu, Y Cheng, Y Chen… - European Journal of …, 2023 - Elsevier
Cerebral small vessel disease (CSVD) is one of the most important causes of stroke and
vascular dementia, so exploring effective treatment modalities for CSVD is warranted. This …
vascular dementia, so exploring effective treatment modalities for CSVD is warranted. This …
[HTML][HTML] Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage through inhibiting TAK1-NF-κB signaling
X Zhang, J Li, C Cao, Z Liu, Q Chen, Z Gu… - International …, 2024 - Elsevier
Oxidative stress and neuroinflammation are two major causes leading to early brain injury
after subarachnoid hemorrhage (SAH). Nuclear factor E2-related factor 2 (Nrf2) is a critical …
after subarachnoid hemorrhage (SAH). Nuclear factor E2-related factor 2 (Nrf2) is a critical …
[HTML][HTML] PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway
Y Fu, L Tao, X Wang, B Wang, W Qin, L Song - Experimental Gerontology, 2024 - Elsevier
Background Mitochondrial dysregulation in skeletal myocytes is considered a major factor in
aged sarcopenia. In this study, we aimed to study the effects of peroxisome proliferator …
aged sarcopenia. In this study, we aimed to study the effects of peroxisome proliferator …
Sestrin2 in POMC neurons modulates energy balance and obesity related metabolic disorders via mTOR signaling
H Hu, X Lu, Y He, J Li, S Wang, Z Luo, Y Wang… - The Journal of …, 2024 - Elsevier
Sestrin2 is a highly conserved protein that can be induced under various stress conditions.
Researches have revealed that the signaling pathway of the mammalian target of rapamycin …
Researches have revealed that the signaling pathway of the mammalian target of rapamycin …
[HTML][HTML] Investigating the Antidepressant Mechanisms of Polygonum sibiricum Polysaccharides via Microglial Polarization
Y Zhang, D Wang, J Liu, J Sun, X Liu, B Fan, C Lu… - Nutrients, 2024 - mdpi.com
Polygonum sibiricum, with its medicinal and edibility dual properties, has been widely
recognized and utilized throughout Chinese history. As a kind of its effective component …
recognized and utilized throughout Chinese history. As a kind of its effective component …
ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway
Y Li, TT Wan, JX Li, X Xiao, L Liu, HH Li… - Molecular Neurobiology, 2024 - Springer
Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated
encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a …
encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a …
[HTML][HTML] Significance of serum sestrin2 as a biomarker of severity and functional outcome in acute intracerebral hemorrhage: a prospective observational longitudinal …
X Dou, W Dong, Y Gu, T Zhang, J Zhang - BMC neurology, 2023 - Springer
Background Sestrin2 is a highly conserved stress-inducible protein with neuroprotective
properties. Herein, we investigated the prognostic significance of serum sestrin2 in human …
properties. Herein, we investigated the prognostic significance of serum sestrin2 in human …
Sestrin2 remedies neuroinflammatory response by inhibiting A1 astrocyte conversion via autophagy
Z Pan, X Yu, W Wang, K Shen, J Chen… - Journal of …, 2024 - Wiley Online Library
Most central nervous diseases are accompanied by astrocyte activation. Autophagy, an
important pathway for cells to protect themselves and maintain homeostasis, is widely …
important pathway for cells to protect themselves and maintain homeostasis, is widely …
Sestrin2 Protects Human Lens Epithelial Cells (HLECs) Against Apoptosis in Cataracts Formation: Interaction Between Endoplasmic Reticulum (ER) Stress and …
D Sun, H Cui, L Rong, T Ma, X Li, Z Ye… - Current Eye …, 2024 - Taylor & Francis
Purpose To explore the correlation of endoplasmic reticulum stress (ERS) and oxidative
stress (OS), and the protective effect of Sestrin2 (SESN2) on human lens epithelial cells …
stress (OS), and the protective effect of Sestrin2 (SESN2) on human lens epithelial cells …