Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Skeletal muscle plays important roles in normal biological activities and whole-body energy
homeostasis in humans. The growth and development of skeletal muscle also directly …

The prevalence of obesity has increased dramatically during the past decades, which has
been a major health problem. Since 1975, the number of people with obesity worldwide has …

Periodontitis is an infectious disease caused by an imbalance between the local microbiota
and host immune response. Epidemiologically, periodontitis is closely related to the …

Adipokines provide an outstanding role in the comprehensive etiology of obesity and may
link adipose tissue dysfunction to further metabolic and cardiovascular complications …

Urologic cancers (UC) account for 13.1% of all new cancer cases and 7.9% of all cancer-
related deaths. A growing body of evidence has indicated a potential causal link between …

Sarcopenia is a disease that becomes more prevalent as the population ages, since it is
directly linked to the process of senility, which courses with muscle atrophy and loss of …

Schizophrenia is a debilitating psychiatric disorder that is treated with antipsychotics.
However, despite their efficacy, antipsychotics increase the risk of metabolic disorders in a …

Estrogen plays a prominent role in regulating and coordinating energy homeostasis
throughout the growth, development, reproduction, and aging of women. Estrogen receptors …

Dysregulated lipid metabolism is a key pathology in metabolic diseases and the liver is a
critical organ for lipid metabolism. The gut microbiota has been shown to regulate hepatic …