Hepatitis B is an infectious hepatocellular disease of global concern caused by hepatitis B
virus (HBV), which belongs to Hepadnaviridae. Recently, a novel HBV-like virus, domestic …

Hepatitis B virus (HBV) is a hepadnavirus, a small DNA virus that infects liver tissue, with
some unusual replication steps that share similarities to retroviruses. HBV infection can lead …

The hepatitis B virus (HBV) ribonuclease H (RNase H) is an attractive but unexploited drug
target. Here, we addressed three limitations to the current state of RNase H inhibitor …

Background: The essential function of HBV DNA polymerase (HBV-DNA-Pol) is to initiate
viral replication by reverse transcription; however, the role of HBV-DNA-Pol in HBV …

Viral circDNA derived from insect positive-sense single-stranded RNA viruses plays a
crucial role in regulating viral infections depending on the RNAi pathway. Our previous …

Abstract Ribonucleases H (RNases H) are Mg 2+-dependent enzymes that cleave RNA
when it is bound to DNA and have vital roles in important cellular processes like replication …

Hepatitis B infections are estimated to affect more than 2 billion people worldwide. The
overall prevalence of HBsAg positivity in plasma is reported to be 3.5%, but it varies …

We aim at the presentation of a newly emerging domestic cat hepadnavirus (DCH), the
causative agent of chronic hepatitis, hepatic fibrosis and hepatocellular carcinoma, which …