Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …

Background & Aims Machine perfusion is a novel method intended to optimize livers before
transplantation. However, its effect on morbidity within a 1-year period after transplantation …

Conventional two-dimensional differentiation from pluripotency fails to recapitulate cell
interactions occurring during organogenesis. Three-dimensional organoids generate …

Kupffer cells (KCs) are highly abundant, intravascular, liver-resident macrophages known for
their scavenger and phagocytic functions. KCs can also present antigens to CD8+ T cells …

Portal vein thrombosis unrelated to solid malignancy is common in patients with cirrhosis,
but less frequently observed in patients without cirrhosis. Prompt diagnosis and …

The liver performs numerous vital functions, including the detoxification of blood before
access to the brain while simultaneously secreting and internalizing scores of proteins and …

The interest in the liver dates back to ancient times when it was considered to be the seat of
life processes. The liver is indeed essential to life, not only due to its complex functions in …

Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver
inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer but the …

Hepatic ischemia–reperfusion (IR) injury is a common clinical issue lacking effective therapy
and validated pharmacological targets. Here, using integrative'omics' analysis, we identified …