The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

In developed countries, aging is often seen as typical, but it is made complicated by many
disorders and co-morbidities. Insulin resistance seems to be an underlying pathomechanism …

Age-associated myometrial dysfunction can prompt complications during pregnancy and
labor, which is one of the factors contributing to the 7.8-fold increase in maternal mortality in …

Individuals with spinal cord injury (SCI) have higher infection rates compared to those
without SCI. In this review, the immune status difference between individuals with and …

External signs of disease are frequently used as indicators of disease susceptibility.
However, immune profiling can be a more effective indicator to understand how host …

Osteoporosis commonly occurs in the older people and severe patients, with the main
reason of the imbalance of bone metabolism (the rate of bone resorption exceeding the rate …

Melatonin, a hormone secreted by the pineal gland of vertebrates, regulates sleep, blood
pressure, and circadian and seasonal rhythms, and acts as an antioxidant and anti …

Periodontal diseases are highly prevalent in populations worldwide and are a major global
public health problem, with major negative impacts on individuals and communities. This …

Impressive advances have been made to replicate human physiology in vitro over the last
few years due to the growth of the organ-on-chip (OoC) field in both industrial and academic …

Increasing evidence suggests that there is acceleration of lung ageing in chronic lung
diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary …