⍺-Synuclein levels in Parkinson's disease–Cell types and forms that contribute to pathogenesis
GT Sagredo, O Tanglay, S Shahdadpuri, YH Fu… - Experimental …, 2024 - Elsevier
Parkinson's disease (PD) has two main pathological hallmarks, the loss of nigral dopamine
neurons and the proteinaceous aggregations of⍺-synuclein (⍺ Syn) in neuronal Lewy …
neurons and the proteinaceous aggregations of⍺-synuclein (⍺ Syn) in neuronal Lewy …
Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy
M Jafari, A Macho-González, A Diaz… - Proceedings of the …, 2024 - National Acad Sciences
Chaperone-mediated autophagy (CMA) is part of the mammalian cellular proteostasis
network that ensures protein quality control, maintenance of proteome homeostasis, and …
network that ensures protein quality control, maintenance of proteome homeostasis, and …
Neurosteroids and their potential as a safer class of general anesthetics
H Tateiwa, AS Evers - Journal of Anesthesia, 2024 - Springer
Neurosteroids (NS) are a class of steroids that are synthesized within the central nervous
system (CNS). Various NS can either enhance or inhibit CNS excitability and they play …
system (CNS). Various NS can either enhance or inhibit CNS excitability and they play …
Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia
W Lai, R Luo, Y Tang, Z Yu, B Zhou… - Phytotherapy …, 2024 - Wiley Online Library
Salidroside, a principal bioactive component of Rhodiola crenulata, is neuroprotective
across a wide time window in stroke models. We investigated whether salidroside induced …
across a wide time window in stroke models. We investigated whether salidroside induced …
ALKBH1 promotes HIF-1α-mediated glycolysis by inhibiting N-glycosylation of LAMP2A
Y Liu, M Li, M Lin, X Liu, H Guo, J Tan, L Hu, J Li… - Cellular and Molecular …, 2024 - Springer
ALKBH1 is a typical demethylase of nucleic acids, which is correlated with multiple types of
biological processes and human diseases. Recent studies are focused on the demethylation …
biological processes and human diseases. Recent studies are focused on the demethylation …
[HTML][HTML] Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets
D Lin, W Lai, N Zheng, H Luo, X Chen, W Que… - Frontiers in …, 2024 - frontiersin.org
Objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease. Its pathogenesis
has not yet been clarified, so it is urgent to explore therapeutic targets. Here, we clarified the …
has not yet been clarified, so it is urgent to explore therapeutic targets. Here, we clarified the …
Analysis of gene expression in microglial apoptotic cell clearance following spinal cord injury based on machine learning algorithms
L Yan, C Chen, L Wang, H Hong… - Experimental and …, 2024 - spandidos-publications.com
Spinal cord injury (SCI) is a severe neurological complication following spinal fracture,
which has long posed a challenge for clinicians. Microglia play a dual role in the …
which has long posed a challenge for clinicians. Microglia play a dual role in the …
[HTML][HTML] 分子伴侣介导的自噬对胆红素诱导的小鼠小胶质细胞损伤的影响
潘知繁， 李思宇， 李玲， 张燕， 华子瑜 - Chinese Journal of …, 2024 - ncbi.nlm.nih.gov
分子伴侣介导的自噬对胆红素诱导的小鼠小胶质细胞损伤的影响- PMC Back to Top Skip to main
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …
Lycium Barbarum Glycopeptide Alleviates Retinal Inflammation by Suppressing Microglial M1 Polarization via NF-κB/MAPK Pathways
Y Ou, Y Huang, X Yang, L Li, R Mei, Z Yu, KF So… - 2024 - preprints.org
Microglia-related retinal inflammation is associated with a variety of retinal diseases. Lycium
barbarum Glycopeptide (LBGP) is the main active component of Lycium barbarum …
barbarum Glycopeptide (LBGP) is the main active component of Lycium barbarum …
Impact of chaperone-mediated autophagy on bilirubin-induced damage of mouse microglial cells
ZF Pan, SY Li, L Li, Y Zhang, ZY Hua - Zhongguo Dang dai er ke za …, 2024 - europepmc.org
Objectives To investigate the effect of chaperone-mediated autophagy (CMA) on the
damage of mouse microglial BV2 cells induce by unconjugated bilirubin (UCB). Methods …
damage of mouse microglial BV2 cells induce by unconjugated bilirubin (UCB). Methods …